Intramolecular proton transfer impact on antibacterial properties of ansamycin antibiotic rifampicin and its new amino analogues.
نویسندگان
چکیده
Intramolecular proton transfer in rifampicin (1) and its analogues 2-9 with the formation of zwitterions has been indicated by multinuclear NMR and crystallographic studies. Biological tests of 1-9 in combination with the analysis of ligand-protein interactions have revealed the relationship between the protonation site and extremely high antibacterial activity.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 10 12 شماره
صفحات -
تاریخ انتشار 2012